Nitroxyl radicals: electrochemical redox behaviour and structure-activity relationships.
نویسندگان
چکیده
Comparative study of electrochemical redox behaviour of five different nitroxyl radicals leads to the direct correlation between one-electron redox potentials and group electronegativity of the beta-substituent on the ring. Beta-substituents with an electron-donating effect caused a negative shift in the one-electron oxidation and one-electron reduction potentials of the nitroxyl radicals. In a similar aspect, beta-substituents with an electron-withdrawing effect behaved oppositely.
منابع مشابه
Effect of oxygen on the electrochemical reduction of nitroxyl radical: interpretation of the mechanism for a redox probe in biological systems.
Though this reaction has been widely employed as a redox probe in biological systems,1–4 we have a question as to why the reduced form of the nitroxyl radicals effectively works as a redox probe for oxidative stress in vivo regardless of their slow oxidation at electrodes, and their irreversible electrochemical property.5–7 We cannot help commenting that its reaction mechanism has been sufficie...
متن کاملElectron spin resonance spectroscopy studies on reduction process of nitroxyl radicals used in molecular imaging
Electron spin resonance (ESR) spectroscopy studies on the reduction process of nitroxyl radicals were carried out for 1mM concentration of 14 N-labeled nitroxyl radicals in 1 mM concentration of ascorbic acid as a function of time. The half life time and decay rate were estimated for 1mM concentration of 14 N labeled nitroxyl radicals in 1 mM concentration of ascorbic acid. From the results, th...
متن کاملElectrochemical Alcohol Oxidation Mediated by TEMPO‐like Nitroxyl Radicals
The electrocatalytic oxidation of alcohols mediated by TEMPO-like nitroxyl radicals is an economically and industrially viable method that will shortly find commercial application in the synthesis of valued substances including active pharmaceutical ingredients (APIs), valued natural product derivatives, fine chemicals, and valued nanomaterials.
متن کاملNovel pharmacokinetic measurement using electron paramagnetic resonance spectroscopy and simulation of in vivo decay of various nitroxyl spin probes in mouse blood.
A novel approach to measure the time course of paramagnetic spin probe concentration in the circulating blood of a living mouse using X-band (9.4 GHz) electron paramagnetic resonance spectrometer is described. Using this technique, the pharmacokinetics of several nitroxyl spin probes was examined. The decay profiles were also independently simulated using pharmacokinetic properties as well as r...
متن کاملPlatinum Complexes with Bioactive Nitroxyl Radicals: Synthesis and Antitumor Properties
Nitroxyl radicals (NRs), which are sometimes called "organic nitrogen oxides” exhibit a wide range of biological activities, e.g., hemodynamic effect, protection against ionizing radiation, suppression of oxidative stress in different types of pathology (Soule et al., 2007; Wilcox, 2010). Already in early studies of the simplest NRs, their antitumor activity was demonstrated on a model tumor, l...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 5 24 شماره
صفحات -
تاریخ انتشار 2007